Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88

MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that MyD88 plays a critical role in EAE, the murine model of multiple sclerosis, and showed that the MyD88 BB-loop decoy peptide RDVLPGT ameliorat...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Dishon, Shira, Schumacher, Adi, Fanous, Joseph, Talhami, Alaa, Kassis, Ibrahim, Karussis, Dimitrios, Gilon, Chaim, Hoffman, Amnon, Nussbaum, Gabriel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013495/
https://ncbi.nlm.nih.gov/pubmed/29930295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27773-8
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