Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution structural data of arrestins bound to phosphorylated receptor C-termini, the functional role of each phosphorylation si...

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Pubblicato in:Nat Commun
Autori principali: Mayer, Daniel, Damberger, Fred F., Samarasimhareddy, Mamidi, Feldmueller, Miki, Vuckovic, Ziva, Flock, Tilman, Bauer, Brian, Mutt, Eshita, Zosel, Franziska, Allain, Frédéric H. T., Standfuss, Jörg, Schertler, Gebhard F. X., Deupi, Xavier, Sommer, Martha E., Hurevich, Mattan, Friedler, Assaf, Veprintsev, Dmitry B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424980/
https://ncbi.nlm.nih.gov/pubmed/30890705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09204-y
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