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Computational design of thermostabilizing point mutations for G protein-coupled receptors
Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational approach to effective prediction of stabilizing muta...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6013254/ https://ncbi.nlm.nih.gov/pubmed/29927385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34729 |
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