Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

Structural studies of human G protein-coupled receptors (GPCRs) have recently been accelerated through the use of the T4 lysozyme fusion partner that was inserted into the third intracellular loop. Using chimeras of the human β(2)-adrenergic and human A(2A) adenosine receptors, we present the method...

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Detalhes bibliográficos
Main Authors: Chun, Eugene, Thompson, Aaron A., Liu, Wei, Roth, Christopher B., Griffith, Mark T., Katritch, Vsevolod, Kunken, Joshua, Xu, Fei, Cherezov, Vadim, Hanson, Michael A., Stevens, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375611/
https://ncbi.nlm.nih.gov/pubmed/22681902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.04.010
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