Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia

Immunoglobulins (Ig) are produced by B lymphocytes as secreted antibodies or as part of the B-cell receptor. There is tremendous diversity of potential Ig transcripts (>1 × 10(12)) as a result of hundreds of germ-line gene segments, random nucleotide incorporation during joining of gene segments...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Blachly, James S., Ruppert, Amy S., Zhao, Weiqiang, Long, Susan, Flynn, Joseph, Flinn, Ian, Jones, Jeffrey, Maddocks, Kami, Andritsos, Leslie, Ghia, Emanuela M., Rassenti, Laura Z., Kipps, Thomas J., de la Chapelle, Albert, Byrd, John C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394264/
https://ncbi.nlm.nih.gov/pubmed/25787252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503587112
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