Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia

Immunoglobulins (Ig) are produced by B lymphocytes as secreted antibodies or as part of the B-cell receptor. There is tremendous diversity of potential Ig transcripts (>1 × 10(12)) as a result of hundreds of germ-line gene segments, random nucleotide incorporation during joining of gene segments...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Blachly, James S., Ruppert, Amy S., Zhao, Weiqiang, Long, Susan, Flynn, Joseph, Flinn, Ian, Jones, Jeffrey, Maddocks, Kami, Andritsos, Leslie, Ghia, Emanuela M., Rassenti, Laura Z., Kipps, Thomas J., de la Chapelle, Albert, Byrd, John C.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394264/
https://ncbi.nlm.nih.gov/pubmed/25787252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503587112
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires