Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia

Immunoglobulins (Ig) are produced by B lymphocytes as secreted antibodies or as part of the B-cell receptor. There is tremendous diversity of potential Ig transcripts (>1 × 10(12)) as a result of hundreds of germ-line gene segments, random nucleotide incorporation during joining of gene segments...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Blachly, James S., Ruppert, Amy S., Zhao, Weiqiang, Long, Susan, Flynn, Joseph, Flinn, Ian, Jones, Jeffrey, Maddocks, Kami, Andritsos, Leslie, Ghia, Emanuela M., Rassenti, Laura Z., Kipps, Thomas J., de la Chapelle, Albert, Byrd, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394264/
https://ncbi.nlm.nih.gov/pubmed/25787252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503587112
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