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Brk/Protein Tyrosine Kinase 6 Phosphorylates p27(KIP1), Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4
Cyclin D and cyclin-dependent kinase 4 (cdk4) are overexpressed in a variety of tumors, but their levels are not accurate indicators of oncogenic activity because an accessory factor such as p27(Kip1) is required to assemble this unstable dimer. Additionally, tyrosine (Y) phosphorylation of p27 (pY8...
में बचाया:
| में प्रकाशित: | Mol Cell Biol |
|---|---|
| मुख्य लेखकों: | , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society for Microbiology
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4387217/ https://ncbi.nlm.nih.gov/pubmed/25733683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01206-14 |
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