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Differential Modification of p27(Kip1) Controls Its Cyclin D-cdk4 Inhibitory Activity
Whether p27 is a cyclin D-cdk4/6 inhibitor or not is controversial, and how it might switch between these two modes is unknown. Arguing for a two-state mechanism, we show that p27 bound to cyclin D-cdk4 can be both inhibitory and noninhibitory, due to its differential-growth-state-dependent tyrosine...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology (ASM)
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2223302/ https://ncbi.nlm.nih.gov/pubmed/17908796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02171-06 |
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