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Phosphorylation of p27(Kip1) Regulates Assembly and Activation of Cyclin D1-Cdk4

p27 mediates Cdk2 inhibition and is also found in cyclin D1-Cdk4 complexes. The present data support a role for p27 in the assembly of D-type cyclin-Cdk complexes and indicate that both cyclin D1-Cdk4-p27 assembly and kinase activation are regulated by p27 phosphorylation. Prior work showed that p27...

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Bibliografske podrobnosti
Main Authors: Larrea, Michelle D., Liang, Jiyong, Da Silva, Thiago, Hong, Feng, Shao, Shan H., Han, Kathy, Dumont, D., Slingerland, Joyce M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577417/
https://ncbi.nlm.nih.gov/pubmed/18710949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02300-07
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