RSK1 drives p27(Kip1) phosphorylation at T198 to promote RhoA inhibition and increase cell motility

p90 ribosomal S6 kinase (RSK1) is an effector of both Ras/MEK/MAPK and PI3K/PDK1 pathways. We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility. RSK1 activation and p27pT198 both increase in early G(1). As for many kinase–substrate pairs, ce...

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Detalhes bibliográficos
Main Authors: Larrea, Michelle D., Hong, Feng, Wander, Seth A., da Silva, Thiago G., Helfman, David, Lannigan, Deborah, Smith, Jeffrey A., Slingerland, Joyce M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695095/
https://ncbi.nlm.nih.gov/pubmed/19470470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805057106
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