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Brk/Protein Tyrosine Kinase 6 Phosphorylates p27(KIP1), Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4

Cyclin D and cyclin-dependent kinase 4 (cdk4) are overexpressed in a variety of tumors, but their levels are not accurate indicators of oncogenic activity because an accessory factor such as p27(Kip1) is required to assemble this unstable dimer. Additionally, tyrosine (Y) phosphorylation of p27 (pY8...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Patel, Priyank, Asbach, Benedikt, Shteyn, Elina, Gomez, Cindy, Coltoff, Alexander, Bhuyan, Sadia, Tyner, Angela L., Wagner, Ralf, Blain, Stacy W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387217/
https://ncbi.nlm.nih.gov/pubmed/25733683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01206-14
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