Brk/Protein Tyrosine Kinase 6 Phosphorylates p27(KIP1), Regulating the Activity of Cyclin D–Cyclin-Dependent Kinase 4

Cyclin D and cyclin-dependent kinase 4 (cdk4) are overexpressed in a variety of tumors, but their levels are not accurate indicators of oncogenic activity because an accessory factor such as p27(Kip1) is required to assemble this unstable dimer. Additionally, tyrosine (Y) phosphorylation of p27 (pY8...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Patel, Priyank, Asbach, Benedikt, Shteyn, Elina, Gomez, Cindy, Coltoff, Alexander, Bhuyan, Sadia, Tyner, Angela L., Wagner, Ralf, Blain, Stacy W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387217/
https://ncbi.nlm.nih.gov/pubmed/25733683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01206-14
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