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Tyrosine phosphorylation of p27Kip1 correlates with Palbociclib responsiveness in breast cancer tumor cells grown in explant culture
Cdk4 targeting drugs, such as Palbociclib, are approved for metastatic ER/PR+, Her2− breast cancer. However, other than loss of Rb, which is very rare in this subset, there are no biomarkers to predict response. Cyclin D or cdk4 levels are not by themselves indicative, since p27Kip1 is required for...
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| Publicado en: | Mol Cancer Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6397661/ https://ncbi.nlm.nih.gov/pubmed/30559257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0188 |
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