Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration

OBJECTIVE: Haptoglobin (Hp) is an approved treatment in Japan with indications for trauma, burns and massive transfusion related hemolysis. Additional case reports suggest uses in other acute hemolytic events that lead to acute kidney injury. However, Hp's protective effects on the pulmonary va...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Free Radic Biol Med
Prif Awduron: Irwin, David C., Baek, Jin Hyen, Hassell, Kathryn, Nuss, Rachelle, Eigenberger, Paul, Lisk, Christina, Loomis, Zoe, Maltzahn, Joanne, Stenmark, Kurt R, Nozik-Grayck, Eva, Buehler, Paul W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387123/
https://ncbi.nlm.nih.gov/pubmed/25656991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.01.012
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