Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration

OBJECTIVE: Haptoglobin (Hp) is an approved treatment in Japan with indications for trauma, burns and massive transfusion related hemolysis. Additional case reports suggest uses in other acute hemolytic events that lead to acute kidney injury. However, Hp's protective effects on the pulmonary va...

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Publicado no:Free Radic Biol Med
Main Authors: Irwin, David C., Baek, Jin Hyen, Hassell, Kathryn, Nuss, Rachelle, Eigenberger, Paul, Lisk, Christina, Loomis, Zoe, Maltzahn, Joanne, Stenmark, Kurt R, Nozik-Grayck, Eva, Buehler, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387123/
https://ncbi.nlm.nih.gov/pubmed/25656991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.01.012
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