Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation

It is now well established that both inherited and acquired forms of hemolytic disease can promote pulmonary vascular disease consequent of free hemoglobin (Hb) induced NO scavenging, elevations in reactive oxygen species and lipid peroxidation. It has recently been reported that oxidative stress ca...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Loomis, Zoe, Eigenberger, Paul, Redinius, Katherine, Lisk, Christina, Karoor, Vijaya, Nozik-Grayck, Eva, Ferguson, Scott K., Hassell, Kathryn, Nuss, Rachelle, Stenmark, Kurt, Buehler, Paul, Irwin, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289566/
https://ncbi.nlm.nih.gov/pubmed/28152051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171219
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