Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism

Cell-free hemoglobin (Hb) exposure may be a pathogenic mediator in the development of pulmonary arterial hypertension (PAH), and when combined with chronic hypoxia the potential for exacerbation of PAH and vascular remodeling is likely more pronounced. We hypothesized that Hb may contribute to hypox...

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Detalhes bibliográficos
Main Authors: Buehler, Paul W., Baek, Jin Hyen, Lisk, Christina, Connor, Ian, Sullivan, Tim, Kominsky, Douglas, Majka, Susan, Stenmark, Kurt R., Nozik-Grayck, Eva, Bonaventura, Joe, Irwin, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423829/
https://ncbi.nlm.nih.gov/pubmed/22728465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00074.2012
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