Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism

Cell-free hemoglobin (Hb) exposure may be a pathogenic mediator in the development of pulmonary arterial hypertension (PAH), and when combined with chronic hypoxia the potential for exacerbation of PAH and vascular remodeling is likely more pronounced. We hypothesized that Hb may contribute to hypox...

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Hlavní autoři: Buehler, Paul W., Baek, Jin Hyen, Lisk, Christina, Connor, Ian, Sullivan, Tim, Kominsky, Douglas, Majka, Susan, Stenmark, Kurt R., Nozik-Grayck, Eva, Bonaventura, Joe, Irwin, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423829/
https://ncbi.nlm.nih.gov/pubmed/22728465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00074.2012
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