Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration

OBJECTIVE: Haptoglobin (Hp) is an approved treatment in Japan with indications for trauma, burns and massive transfusion related hemolysis. Additional case reports suggest uses in other acute hemolytic events that lead to acute kidney injury. However, Hp's protective effects on the pulmonary va...

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Detaylı Bibliyografya
Yayımlandı:Free Radic Biol Med
Asıl Yazarlar: Irwin, David C., Baek, Jin Hyen, Hassell, Kathryn, Nuss, Rachelle, Eigenberger, Paul, Lisk, Christina, Loomis, Zoe, Maltzahn, Joanne, Stenmark, Kurt R, Nozik-Grayck, Eva, Buehler, Paul W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387123/
https://ncbi.nlm.nih.gov/pubmed/25656991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.01.012
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