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Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration

OBJECTIVE: Haptoglobin (Hp) is an approved treatment in Japan with indications for trauma, burns and massive transfusion related hemolysis. Additional case reports suggest uses in other acute hemolytic events that lead to acute kidney injury. However, Hp's protective effects on the pulmonary va...

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Publicat a:Free Radic Biol Med
Autors principals: Irwin, David C., Baek, Jin Hyen, Hassell, Kathryn, Nuss, Rachelle, Eigenberger, Paul, Lisk, Christina, Loomis, Zoe, Maltzahn, Joanne, Stenmark, Kurt R, Nozik-Grayck, Eva, Buehler, Paul W.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387123/
https://ncbi.nlm.nih.gov/pubmed/25656991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.01.012
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