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Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration
OBJECTIVE: Haptoglobin (Hp) is an approved treatment in Japan with indications for trauma, burns and massive transfusion related hemolysis. Additional case reports suggest uses in other acute hemolytic events that lead to acute kidney injury. However, Hp's protective effects on the pulmonary va...
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Publicat a: | Free Radic Biol Med |
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Autors principals: | , , , , , , , , , , |
Format: | Artigo |
Idioma: | Inglês |
Publicat: |
2015
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4387123/ https://ncbi.nlm.nih.gov/pubmed/25656991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.01.012 |
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