Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats

Batracylin (NSC-320846) is a dual inhibitor of DNA topoisomerases I and II. Batracylin advanced as an anticancer agent to Phase I clinical trials where dose limiting hemorrhagic cystitis (bladder inflammation and bleeding) was observed. To further investigate batracylin’s mechanism of toxicity, stud...

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Detalhes bibliográficos
Publicado no:Toxicol Pathol
Main Authors: Davis, Myrtle, Bunin, Deborah I., Samuelsson, Steven J., Altera, Kenneth P., Kinders, Robert J., Lawrence, Scott M, Ji, Jiuping, Ames, Matthew M., Buhrow, Sarah A., Walden, Chad, Reid, Joel M., Rausch, Linda L., Parman, Toufan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382466/
https://ncbi.nlm.nih.gov/pubmed/25274659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623314548766
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