Comparative Uterotrophic Effects of Endoxifen and Tamoxifen in Ovariectomized Sprague Dawley Rats

Endoxifen (4-hydroxyl-N-desmethyl tamoxifen), one of the major active metabolites of tamoxifen, has substantially greater estrogen antagonist properties and antiproliferative effects in breast tumor cells than tamoxifen, a mixed estrogen agonist/antagonist. An associated risk of endometrial cancer a...

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Main Authors: Schweikart, Karen M., Eldridge, Sandy R., Safgren, Stephanie L., Parman, Toufan, Reid, Joel M., Ames, Matthew M., Goetz, Matthew P., Davis, Myrtle A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177029/
https://ncbi.nlm.nih.gov/pubmed/24670817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623314525688
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