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Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies
BACKGROUND: Reduced CYP2D6 metabolism and low Z-endoxifen (ENDX) concentrations may increase the risk of breast cancer recurrence in tamoxifen (TAM)-treated women. Little is known regarding the differences between TAM and ENDX murine pharmacokinetics or the effect of administration route on plasma c...
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| Publicado no: | Cancer Chemother Pharmacol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4343319/ https://ncbi.nlm.nih.gov/pubmed/25318936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2605-7 |
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