Evaluation of CYP2D6 enzyme activity using a Dextromethorphan Breath Test in Women Receiving Adjuvant Tamoxifen

BACKGROUND: In tamoxifen-treated patients, breast cancer recurrence differs according to CYP2D6 genotype and endoxifen steady state concentrations (Endx Css). The 13Cdextromethorphan breath test (DM-BT), labeled with 13C at the O-CH3 moiety, measures CYP2D6 enzyme activity. We sought to examine the...

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Detalhes bibliográficos
Publicado no:Pharmacogenet Genomics
Main Authors: Safgren, Stephanie L., Suman, Vera J., Kosel, Matthew L., Gilbert, Judith A, Buhrow, Sarah A., Black, John L., Northfelt, Donald W., Modak, Anil S., Rosen, David, Ingle, James N., Ames, Matthew M., Reid, Joel M., Goetz, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356640/
https://ncbi.nlm.nih.gov/pubmed/25714002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000121
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