SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen

AIM: Tamoxifen biotransformation to endoxifen, a potent antiestrogen, is catalyzed by CYP2D6. In addition, CYP2C19 and SULT1A1 have also been implicated in the metabolism of tamoxifen. We sought to evaluate the importance of SULT1A1 copy number and CYP2C19*17 on disease-free survival (DFS) in postme...

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Main Authors: Moyer, Ann M, Suman, Vera J, Weinshilboum, Richard M, Avula, Rajeswari, Black, John L, Safgren, Stephanie L, Kuffel, Mary J, Ames, Matthew M, Ingle, James N, Goetz, Matthew P
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235041/
https://ncbi.nlm.nih.gov/pubmed/21961651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.11.97
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