Coprescription of Tamoxifen and Medications That Inhibit CYP2D6

Evidence has emerged that the clinical benefit of tamoxifen is related to the functional status of the hepatic metabolizing enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6 is the key enzyme responsible for the generation of the potent tamoxifen metabolite, endoxifen. Multiple studies have examined the r...

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Detalhes bibliográficos
Main Authors: Sideras, Kostandinos, Ingle, James N., Ames, Matthew M., Loprinzi, Charles L., Mrazek, David P., Black, John L., Weinshilboum, Richard M., Hawse, John R., Spelsberg, Thomas C., Goetz, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881853/
https://ncbi.nlm.nih.gov/pubmed/20439629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.23.8931
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