Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats

Batracylin (NSC-320846) is a dual inhibitor of DNA topoisomerases I and II. Batracylin advanced as an anticancer agent to Phase I clinical trials where dose limiting hemorrhagic cystitis (bladder inflammation and bleeding) was observed. To further investigate batracylin’s mechanism of toxicity, stud...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Pathol
Prif Awduron: Davis, Myrtle, Bunin, Deborah I., Samuelsson, Steven J., Altera, Kenneth P., Kinders, Robert J., Lawrence, Scott M, Ji, Jiuping, Ames, Matthew M., Buhrow, Sarah A., Walden, Chad, Reid, Joel M., Rausch, Linda L., Parman, Toufan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382466/
https://ncbi.nlm.nih.gov/pubmed/25274659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623314548766
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