Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats

Batracylin (NSC-320846) is a dual inhibitor of DNA topoisomerases I and II. Batracylin advanced as an anticancer agent to Phase I clinical trials where dose limiting hemorrhagic cystitis (bladder inflammation and bleeding) was observed. To further investigate batracylin’s mechanism of toxicity, stud...

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Bibliographic Details
Published in:Toxicol Pathol
Main Authors: Davis, Myrtle, Bunin, Deborah I., Samuelsson, Steven J., Altera, Kenneth P., Kinders, Robert J., Lawrence, Scott M, Ji, Jiuping, Ames, Matthew M., Buhrow, Sarah A., Walden, Chad, Reid, Joel M., Rausch, Linda L., Parman, Toufan
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382466/
https://ncbi.nlm.nih.gov/pubmed/25274659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623314548766
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