Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymphoblastic leukaemias from diagnosis to relapse. We show that clonal diversi...

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Publicado en:Nat Commun
Main Authors: Ma, Xiaotu, Edmonson, Michael, Yergeau, Donald, Muzny, Donna M., Hampton, Oliver A., Rusch, Michael, Song, Guangchun, Easton, John, Harvey, Richard C., Wheeler, David A., Ma, Jing, Doddapaneni, HarshaVardhan, Vadodaria, Bhavin, Wu, Gang, Nagahawatte, Panduka, Carroll, William L., Chen, I-Ming, Gastier-Foster, Julie M., Relling, Mary V., Smith, Malcolm A., Devidas, Meenakshi, Auvil, Jaime M. Guidry, Downing, James R., Loh, Mignon L., Willman, Cheryl L., Gerhard, Daniela S., Mullighan, Charles G., Hunger, Stephen P., Zhang, Jinghui
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377644/
https://ncbi.nlm.nih.gov/pubmed/25790293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7604
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