Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

Adults and children with high-risk CRLF2-rearranged acute lymphoblastic leukemia (ALL) respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of relapse, supporting the need to use alternative therapies. CRLF2 encodes the thymic stromal lymphopoietin (TSLP) receptor, whi...

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Autores principales: Tasian, Sarah K., Doral, Michelle Y., Borowitz, Michael J., Wood, Brent L., Chen, I-Ming, Harvey, Richard C., Gastier-Foster, Julie M., Willman, Cheryl L., Hunger, Stephen P., Mullighan, Charles G., Loh, Mignon L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412346/
https://ncbi.nlm.nih.gov/pubmed/22685175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-389932
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