Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia

Philadelphia chromosome (Ph)–like B-cell acute lymphoblastic leukemia (Ph-like ALL) is associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3-kinase (PI3K) signaling and poor clinical outcomes. PI3K pathway signaling inhibitors have been minimally investigated in Ph-...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Tasian, Sarah K., Teachey, David T., Li, Yong, Shen, Feng, Harvey, Richard C., Chen, I-Ming, Ryan, Theresa, Vincent, Tiffaney L., Willman, Cheryl L., Perl, Alexander E., Hunger, Stephen P., Loh, Mignon L., Carroll, Martin, Grupp, Stephan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234216/
https://ncbi.nlm.nih.gov/pubmed/27777238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-707653
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