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mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia
We have previously demonstrated that mTOR inhibitors (MTIs) are active in preclinical models of acute lymphoblastic leukemia (ALL). MTIs may increase degradation of cyclin D1, a protein involved in dihydrofolate reductase (DHFR) synthesis. Because resistance to methotrexate may correlate with high D...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518903/ https://ncbi.nlm.nih.gov/pubmed/18544682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-137141 |
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