Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)–like acute lymphoblastic leukemia (ALL), a recently described subtype of pediatric high-risk B-precursor ALL (B-ALL) which exhibits a gene expression profile similar to Ph-positiv...

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Hlavní autoři: Maude, Shannon L., Tasian, Sarah K., Vincent, Tiffaney, Hall, Junior W., Sheen, Cecilia, Roberts, Kathryn G., Seif, Alix E., Barrett, David M., Chen, I-Ming, Collins, J. Racquel, Mullighan, Charles G., Hunger, Stephen P., Harvey, Richard C., Willman, Cheryl L., Fridman, Jordan S., Loh, Mignon L., Grupp, Stephan A., Teachey, David T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482861/
https://ncbi.nlm.nih.gov/pubmed/22955920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415448
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