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mTOR Inhibitors and Their Potential Role in Therapy in Leukemia and Other Haematologic Malignancies
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulator of cell growth, protein synthesis, and cell-cycle progression through interactions with a number of signaling pathways, including PI3K/AKT, ras, TCL1, and BCR/ABL. Many haematologic malignancies h...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2784662/ https://ncbi.nlm.nih.gov/pubmed/19344392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07657.x |
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