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mTOR inhibitors in cancer therapy
The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation, acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 (mTORC1/2). mTORC1 signaling is switched on by several oncogenic signaling pathways and is accordingly hyperactive in the...
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| Publié dans: | F1000Res |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
F1000Research
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5007757/ https://ncbi.nlm.nih.gov/pubmed/27635236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.9207.1 |
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