Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

We sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias, the largest pediatric cancer genome sequencing effort reported to date. Integrated analysis of 179 validated somatic sequence mutations with genome-wide copy number alterations and gene expression...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Jinghui, Mullighan, Charles G., Harvey, Richard C., Wu, Gang, Chen, Xiang, Edmonson, Michael, Buetow, Kenneth H., Carroll, William L., Chen, I-Ming, Devidas, Meenakshi, Gerhard, Daniela S., Loh, Mignon L., Reaman, Gregory H., Relling, Mary V., Camitta, Bruce M., Bowman, W. Paul, Smith, Malcolm A., Willman, Cheryl L., Downing, James R., Hunger, Stephen P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Clinical Trials and Observations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175785/
https://ncbi.nlm.nih.gov/pubmed/21680795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-341412
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