Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia

There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymphoblastic leukaemias from diagnosis to relapse. We show that clonal diversi...

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Vydáno v:Nat Commun
Hlavní autoři: Ma, Xiaotu, Edmonson, Michael, Yergeau, Donald, Muzny, Donna M., Hampton, Oliver A., Rusch, Michael, Song, Guangchun, Easton, John, Harvey, Richard C., Wheeler, David A., Ma, Jing, Doddapaneni, HarshaVardhan, Vadodaria, Bhavin, Wu, Gang, Nagahawatte, Panduka, Carroll, William L., Chen, I-Ming, Gastier-Foster, Julie M., Relling, Mary V., Smith, Malcolm A., Devidas, Meenakshi, Auvil, Jaime M. Guidry, Downing, James R., Loh, Mignon L., Willman, Cheryl L., Gerhard, Daniela S., Mullighan, Charles G., Hunger, Stephen P., Zhang, Jinghui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377644/
https://ncbi.nlm.nih.gov/pubmed/25790293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7604
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