THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA

Genetic alterations activating NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors are hallmarks of T-ALL, but detailed genome-wide sequencing of large T-ALL cohorts has not been performed. Using integrated genomic analysis of 264 T-ALL case...

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Udgivet i:Nat Genet
Main Authors: Liu, Yu, Easton, John, Shao, Ying, Maciaszek, Jamie, Wang, Zhaoming, Wilkinson, Mark R., McCastlain, Kelly, Edmonson, Michael, Pounds, Stanley B., Shi, Lei, Zhou, Xin, Ma, Xiaotu, Sioson, Edgar, Li, Yongjin, Rusch, Michael, Gupta, Pankaj, Pei, Deqing, Cheng, Cheng, Smith, Malcolm A., Auvil, Jaime Guidry, Gerhard, Daniela S., Relling, Mary V., Winick, Naomi J., Carroll, Andrew J., Heerema, Nyla A., Raetz, Elizabeth, Devidas, Meenakshi, Willman, Cheryl L., Harvey, Richard C., Carroll, William L., Dunsmore, Kimberly P., Winter, Stuart S., Wood, Brent L, Sorrentino, Brian P., Downing, James R., Loh, Mignon L., Hunger, Stephen P, Zhang, Jinghui, Mullighan, Charles G.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535770/
https://ncbi.nlm.nih.gov/pubmed/28671688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3909
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