Intrachromosomal Amplification of Chromosome 21 Is Associated With Inferior Outcomes in Children With Acute Lymphoblastic Leukemia Treated in Contemporary Standard-Risk Children's Oncology Group Studies: A Report From the Children's Oncology Group

PURPOSE: Five-year overall survival (OS) for children with B-cell precursor acute lymphoblastic leukemia (B-ALL) exceeds 90% with risk-adapted therapy. Age, initial WBC count, genetic aberrations, and minimal residual disease (MRD) are used for risk stratification. Intrachromosomal amplification of...

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Główni autorzy: Heerema, Nyla A., Carroll, Andrew J., Devidas, Meenakshi, Loh, Mignon L., Borowitz, Michael J., Gastier-Foster, Julie M., Larsen, Eric C., Mattano, Leonard A., Maloney, Kelly W., Willman, Cheryl L., Wood, Brent L., Winick, Naomi J., Carroll, William L., Hunger, Stephen P., Raetz, Elizabeth A.
Format: Artigo
Język:Inglês
Wydane: American Society of Clinical Oncology 2013
Hasła przedmiotowe:
ORIGINAL REPORTS
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770866/
https://ncbi.nlm.nih.gov/pubmed/23940221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.49.1308
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