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Total Syntheses and Initial Evaluation of [Ψ[C(=S)NH]Tpg(4)]vancomycin, [Ψ[C(=NH)NH]Tpg(4)]vancomycin, [Ψ[CH(2)NH]Tpg(4)]vancomycin and their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modifications for the Glycopeptide Antibiotics
Full details of studies are disclosed on the total synthesis of binding pocket analogues of vancomycin, bearing the peripheral L-vancosaminyl-1,2-D-glucosyl disaccharide, that contain changes to a key single atom in the residue 4 amide (residue 4 carbonyl O → S, NH, H(2)) designed to directly addres...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376669/ https://ncbi.nlm.nih.gov/pubmed/25750995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01008 |
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