Total Syntheses and Initial Evaluation of [Ψ[C(=S)NH]Tpg(4)]vancomycin, [Ψ[C(=NH)NH]Tpg(4)]vancomycin, [Ψ[CH(2)NH]Tpg(4)]vancomycin and their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modifications for the Glycopeptide Antibiotics

Full details of studies are disclosed on the total synthesis of binding pocket analogues of vancomycin, bearing the peripheral L-vancosaminyl-1,2-D-glucosyl disaccharide, that contain changes to a key single atom in the residue 4 amide (residue 4 carbonyl O → S, NH, H(2)) designed to directly addres...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Okano, Akinori, Nakayama, Atsushi, Wu, Kejia, Lindsey, Erick A., Schammel, Alex W., Feng, Yiqing, Collins, Karen C., Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376669/
https://ncbi.nlm.nih.gov/pubmed/25750995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01008
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