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Total Synthesis of [Ψ[C(=NH)NH]Tpg(4)]Vancomycin and its (4-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding
[Image: see text] The total synthesis of two key analogues of vancomycin containing single-atom exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their peripherally modified (4-chlorobiphenyl)methyl (CBP) derivatives. Their assessment indicates that combined...
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| Autors principals: | , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2014
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183650/ https://ncbi.nlm.nih.gov/pubmed/25211770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507009a |
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