A Redesigned Vancomycin Engineered for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria

The emergence of bacteria resistant to vancomycin, often the antibiotic of last resort, poses a major health problem. Vancomycin-resistant bacteria sense a glycopeptide antibiotic challenge and remodel their cell wall precursor peptidoglycan terminus from D-Ala-(d)-Ala to D-Ala-D-Lac, reducing the b...

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Hlavní autoři: Xie, Jian, Pierce, Joshua G., James, Robert C., Okano, Akinori, Boger, Dale L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164945/
https://ncbi.nlm.nih.gov/pubmed/21823662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207142h
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