Synthesis and biological activity of α-glucosyl C24:0 and C20:2 ceramides

α-Glucosyl ceramides 4 and 5 have been synthesised and evaluated for their ability to stimulate the activation and expansion of human iNKT cells. The key challenge in the synthesis of both target molecules was the stereoselective synthesis of the α-glycosidic linkage. Of the methods examined, glycos...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Jervis, Peter J., Veerapen, Natacha, Bricard, Gabriel, Cox, Liam R., Porcelli, Steven A., Besra, Gurdyal S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science Ltd 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374101/
https://ncbi.nlm.nih.gov/pubmed/20529677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.05.010
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