New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

Huisgen [3+2] dipolar cycloaddition of 6″-azido-6″-deoxy-α-galactosyl ceramide 11 with a range of alkynes (or a benzyne precursor) yielded a series of triazole-containing α-galactosyl ceramide (α-GalCer) analogues in high yield. These α-GalCer analogues and the precursor azide 11 were tested for the...

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Hauptverfasser: Jervis, Peter J., Graham, Lisa M., Foster, Erin L., Cox, Liam R., Porcelli, Steven A., Besra, Gurdyal S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science Ltd 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401990/
https://ncbi.nlm.nih.gov/pubmed/22652050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.009
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