Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide

We herein report a faster and less cumbersome synthesis of the biologically attractive, α-galactosyl ceramide (α-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal(α1→2)Ga...

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Hauptverfasser: Veerapen, Natacha, Brigl, Manfred, Garg, Salil, Cerundolo, Vincenzo, Cox, Liam R., Brenner, Michael B., Besra, Gurdyal S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science Ltd 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722241/
https://ncbi.nlm.nih.gov/pubmed/19502056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.05.095
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