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Synthesis of a novel α-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies

A new haptenated derivative of α-galactosyl ceramide (α-GalCer) has been synthesized to assist in the study of the mechanism of T cell help for the production of B cell antibodies. Our synthetic route provides access to an amine intermediate which can easily be extended to generate an array of compo...

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Autores principales: Veerapen, Natacha, Leadbetter, Elizabeth A., Brenner, Michael B., Cox, Liam R., Besra, Gurdyal S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833054/
https://ncbi.nlm.nih.gov/pubmed/20345125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc9005255
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