Synthesis and biological activity of α-glucosyl C24:0 and C20:2 ceramides

α-Glucosyl ceramides 4 and 5 have been synthesised and evaluated for their ability to stimulate the activation and expansion of human iNKT cells. The key challenge in the synthesis of both target molecules was the stereoselective synthesis of the α-glycosidic linkage. Of the methods examined, glycos...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Jervis, Peter J., Veerapen, Natacha, Bricard, Gabriel, Cox, Liam R., Porcelli, Steven A., Besra, Gurdyal S.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science Ltd 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374101/
https://ncbi.nlm.nih.gov/pubmed/20529677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.05.010
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