Codon optimality is a major determinant of mRNA stability

Messenger RNA degradation represents a critical regulated step in gene expression. While the major pathways in turnover have been identified, accounting for disparate half-lives has been elusive. We show that codon optimality is one feature that contributes greatly to mRNA stability. Genome-wide RNA...

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Udgivet i:Cell
Main Authors: Presnyak, Vladimir, Alhusaini, Najwa, Chen, Ying-Hsin, Martin, Sophie, Morris, Nathan, Kline, Nicholas, Olson, Sara, Weinberg, David, Baker, Kristian E., Graveley, Brenton R., Coller, Jeff
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359748/
https://ncbi.nlm.nih.gov/pubmed/25768907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.029
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