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The DEAD-box protein Dhh1p couples mRNA decay and translation by monitoring codon optimality
A major determinant of mRNA half-life is the codon-dependent rate of translational elongation. How the processes of translational elongation and mRNA decay communicate is unclear. Here we establish that the DEAD-box protein Dhh1p is a sensor of codon optimality that targets an mRNA for decay. First,...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635654/ https://ncbi.nlm.nih.gov/pubmed/27641505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.053 |
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