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The DEAD-box protein Dhh1p couples mRNA decay and translation by monitoring codon optimality
A major determinant of mRNA half-life is the codon-dependent rate of translational elongation. How the processes of translational elongation and mRNA decay communicate is unclear. Here we establish that the DEAD-box protein Dhh1p is a sensor of codon optimality that targets an mRNA for decay. First,...
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| Publicat a: | Cell |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5635654/ https://ncbi.nlm.nih.gov/pubmed/27641505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.053 |
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