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The DEAD-box protein Dhh1p couples mRNA decay and translation by monitoring codon optimality

A major determinant of mRNA half-life is the codon-dependent rate of translational elongation. How the processes of translational elongation and mRNA decay communicate is unclear. Here we establish that the DEAD-box protein Dhh1p is a sensor of codon optimality that targets an mRNA for decay. First,...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Radhakrishnan, Aditya, Chen, Ying-Hsin, Martin, Sophie, Alhusaini, Najwa, Green, Rachel, Coller, Jeff
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635654/
https://ncbi.nlm.nih.gov/pubmed/27641505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.053
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