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Codon optimality, bias and usage in translation and mRNA decay

The advent of ribosome profiling and other tools to probe mRNA translation has revealed that codon bias — the uneven use of synonymous codons in the transcriptome —serves as a secondary genetic code: a code that guides the efficiency of protein production, the fidelity of translation and the metabol...

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Pubblicato in:Nat Rev Mol Cell Biol
Autori principali: Hanson, Gavin, Coller, Jeff
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594389/
https://ncbi.nlm.nih.gov/pubmed/29018283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2017.91
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